Indomethacin lisinopril interaction
Indomethacin lisinopril interaction
Coadministration may result in a significant decrease in renal function. Nonsteroidal indomethacin lisinopril interaction anti-inflammatory drugs (NSAIDs) can induce an increase in blood pressure (BP) and may potentially reduce the efficacy of several antihypertensive drugs. Request PDF | Effect of indomethacin on the antihypertensive efficacy of valsartan and lisinopril: A multicentre study | To compare the effect on antihypertensive efficacy produced by the addition. Common interactions include thyroid disorder among females and chronic kidney disease among males. Indomethacin submicronized oral , lisinopril oral pharmacodynamic antagonism. Find out more in the list below:. Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID), prescribed for fever, pain, stiffness and swelling. Lisinopril works by relaxing blood vessels so blood can flow more easily. Consider alternative or monitor potassium, renal fxn, BP: combo may incr. May result in renal function deterioration, particularly in elderly or volume depleted individuals. It is postulated that the effect is due to inhibition of prostaglandin synthesis, which causes sodium retention. Probably the main mechanism of action is inhibition of prostaglandin (PG) synthesis since NSAIDs have higher propensity to increase BP as the regulation of BP (and renal. It can cause lithium to take longer to clear the body. Either increases toxicity of the other by Other (see comment). Antihypertensive agent efficacy; may incr. Lisinopril oral , indomethacin rect. The phase IV clinical study analyzes what indomethacin lisinopril interaction interactions people who take Indomethacin and Lipitor have Interestingly, neither enalapril nor lisinopril appear to show this interaction with indomethacin. Lisinopril + indomethacin consider alternative or monitor BP, renal fxn, potassium: combo may decr. It seems that NSAIDs and the antihypertensive drugs differ in their propensity to such an interaction. 87 mmHg), no significant difference between the two drugs was found Interestingly, neither enalapril nor lisinopril appear to show this interaction with indomethacin. In patients taking amlodipine, the fall in plasma renin ameliorates the effect of sodium retention on BP Indometacin undergoes hepatic metabolism involving glucuronidation, O-desmethylation, and N-deacylation. The phase IV clinical study analyzes what interactions people who take Indomethacin and Fluoxetine have.. Nephropathy antiplatelet effects decreases renal perfusion/fxn GI mucosal injury/bleeding risk hyperkalemia hypertensive effects hyponatremia lowers seizure threshold thrombogenic effects uricosuric effects Avoid/Use Alternative amikacin apixaban aspirin bremelanotide bumetanide. Although indomethacin produced greater increases in both systolic and DBP values in the lisinopril-treated patients (5. Antihypertensive agent efficacy (additive effects; antagonistic effects) diclofenac topical. 87 mmHg), no significant difference between the two drugs was found Indomethacin: An exploratory study of antiviral mechanism and host-pathogen interaction in COVID-19. Indomethacin rect , lisinopril oral pharmacodynamic antagonism. Addition of indomethacin to patients taking either drug caused a rise in weight and a fall in plasma renin. 22 mmHg) than in the valsartan-treated ones (2. Lisinopril oral and indomethacin rect. NSAIDs may diminish the antihypertensive effect of ACE inhibitors lisinopril oral and indomethacin rect.